Noncirrhotic portal hypertension: An under-reported late adverse event of SIRT in metastatic colorectal cancer patients.

Abstract

Selective internal radiation therapy (SIRT) is increasingly used in different scenarios. Although portal hypertension (PHT) has been described as a nonclinically relevant finding after SIRT, its real incidence could have been neglected due to the nature of the diseases for which SIRT is indicated. Here we report three cases with clinically relevant late PHT after treatments including SIRT and oxaliplatin among others. The sequential use of oxaliplatin and SIRT in patients with colorectal cancer metastases could have additive effects on the liver.