Abstract
Nonalcoholic fatty liver disease (NAFLD) has become an emerging health issue with a high prevalence in general population. The cross-sectional study was performed to investigate the association between NAFLD and coronary artery calcification (CAC) in individuals from northern city of China. A total of 2345 participants aged ≥40 (1035 men and 1310 women) were selected from the Jidong community of Tangshan city. Liver ultrasonography was used to the diagnosis of NAFLD. A 64-slice CT scanner was used to determine coronary artery calcification score (CACS), with CACS > 0 defined to be the presence of CAC. The risk level of coronary heart disease (CHD) was graded by CACS according to the 4 commonly used thresholds in clinical practice (0, 10, 100, and 400 Agatston units). NAFLD was significantly associated with CAC (crude OR: 1.631, 95% CI: 1.295–2.053, adjusted OR: 1.348, 95% CI: 1.030–1.765). The association between NAFLD and increased risk level of CHD (Crude OR: 1.639 95% CI: 1.303–2.063; adjusted OR: 1.359 95% CI: 1.043–1.770) was observed. The associations between NAFLD and CAC or increased risk level of CHD were significant in female but not in male. Our finding further confirmed the association between NAFLD and CAC, especially in Asian population.
Highlights
According to the report of the World Health Organization (WHO) in 2012, as a leading cause of morbidity and mortality worldwide which is a main result of coronary atherosclerosis, the coronary heart disease (CHD) has been the most serious global health issue[1]
We aimed to explore the association between Nonalcoholic fatty liver disease (NAFLD) and CAC in a cross-sectional study conducted in a northern Chinese cohort consisting of 2,345 adults who have no history and clinical symptoms of cardiovascular disease
We focused on the association between NAFLD and CAC, and our main findings are as follows: 1) NAFLD was associated with CAC or increased risk level of CHD independent of the traditional risk factors for CHD in Chinese adults
Summary
In order to investigate whether NAFLD is independently associated with CAC, we adjusted age and gender in model 2, age, gender, smoking status, hypertension and diabetes in model 3, and adjusted HC, LDL, physical activity, level of education and income on the basis of model 3 in model 4. Characters Gender n(%) Men Women Age, years (x ± s) Education level n(%) Illiterate or primary Middle/high school College or above Income, ¥/month n(%)*
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