Abstract
Objectives: We aim to describe the epidemiological and prognostic characteristics of non valvular atrial fibrillation related stroke. Patients and methods: We retrospectively analyzed data of hospitalized patients from January 1 st 2010 to June 30th 2012 in the two contiguous departments of cardiology and neurology, at the teaching hospital of Yalgado Ouedraogo, Burkina Faso. Results: We recorded 391 cases of ischaemic stroke. Cardioembolic stroke was observed in 159 patients out of who, non valvular atrial fibrillation accounted for 43.5%. Atrial fibrillation was persistent/permanent in 60 cases (87%). The mean age ± SD was 63.3 ± 14.2 years (extremes: 26-91 years). Hypertension was observed in 85.5% of the cases. The mean CHA 2 DS 2 -VASc score was 4.72 ± 1.16. The mean HAS-BLED score was 2.35 ± 0.92 with a low to intermediate bleeding risk score (≤ 2) in 60.9 % of patients. The rate of vitamin K antagonists use was 52%. They were introduced at least a week after stroke onset in 34 cases. A mean follow up of two weeks in hospital noticed haemorrhagic transformation and ischaemic recurrence in respectively 8.7% and 2.9% of the cases. Mortality rate of 21.7% during hospitalization was predicted by large sized cerebral infarction and congestive heart failure (p<0.05). Conclusion: Non valvular atrial fibrillation stroke is associated with in-hospital high mortality and is subject to early recurrence.
Highlights
Ischaemic stroke is a leading cause of acquired disability and death in adults [1]
We retrospectively analyzed data of hospitalized patients from January 1st 2010 to June 30th 2012 in the two contiguous departments of cardiology and neurology, at the teaching hospital of Yalgado Ouédraogo, Burkina Faso, west Africa. Those were included in the study, patients with ischaemic stroke diagnosed by cranial Computed Tomographic (CT) scan and/or by clinical stroke who presented Atrial fibrillation (AF) confirmed by a standard 12-lead electrocardiogram (ECG) or 24-hours Holter ECG
Cardioembolic stroke was observed in 159 patients out of who, Non Valvular Atrial Fibrillation (NVAF) accounted for 43.5% (43 females and 26 males)
Summary
Ischaemic stroke is a leading cause of acquired disability and death in adults [1]. Cardioembolic stroke accounts for 14-30% of all ischaemic strokes and appears to be associated with higher mortality and early recurrence [2,3]. Atrial fibrillation (AF) is the most common cardiac source of cerebral embolism with many associated risk factors [4,5]. Managing AF alone or with stroke is challenging and costly [68]. Data regarding AF related stroke are scarce in Sub-Saharan African including Burkina Faso. We aim to describe the epidemiological and prognostic characteristics of Non Valvular Atrial Fibrillation (NVAF) related stroke during hospitalization period
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
