Non-utility of sepsis scores for identifying infection in surgical intensive care unit patients

Abstract

BackgroundThe Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) scores replaced the Systemic Inflammatory Response System (SIRS) criteria for defining sepsis, and are often utilized to identify infection, however remain understudied in surgical populations. MethodsDaily SOFA, qSOFA, and SIRS scores were prospectively collected in a surgical/trauma intensive care unit (ICU), comparing scores between patients with and without new infection. Multivariable analysis controlled for ICU type and pre-existing infection. ResultsScores were recorded for 1942 patient-days, including 1385 (71%) with no infection, 439 (23%) with existing/treated infection, and 120 (6.2%) with new infection. Scores were globally elevated, with 98% having SOFA score ≥2, 82% with qSOFA score ≥2, and 92% meeting ≥2 SIRS criteria. Neither univariate nor multivariate analysis revealed a correlation between SOFA, qSOFA, or SIRS score and infection. ConclusionNo scores correlated with new infection, potentially related to increased existing inflammation in this population. SummaryThe Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) have replaced the Systemic Inflammatory Response System (SIRS) criteria for sepsis, however are not well investigated in surgical populations or for identifying infections, as they are often used in practice. In this study, neither daily SOFA, qSOFA, nor SIRS criteria correlated with new infection in a population of critically ill surgical patients. Scores were globally elevated in non-infected patients, potentially related to high levels of existing inflammation in this population.