Non-Ulcerated Necrotizing Sialometaplasia: an Unusual Case Report

Abstract

Necrotizing sialometaplasia, a rare benign condition, occurs due to physical, chemical, or biological traumas. Such factors can cause blood vessel ischemia and generate necrosis in the salivary gland acini. Consequently, the salivary gland ducts undergo squamous metaplasia to promote the repair of the region. A 27-year-old woman presented with a nodule of firm consistency in the posterior region of the palate and an intense painful symptomatology. The patient noticed the lesion during the onset of a sinusitis, which was treated for 21 days with antibiotics and corticoid drugs. No previous history of trauma or systemic alterations was reported. An incisional biopsy was performed, and no painful symptomatology was observed after 10 days. The histopathological diagnosis and immunohistochemical profile (AE1/AE3, CK7, p63, p53, S-100, SMA, and KI-67) were consistent with a non-ulcerated necrotizing sialometaplasia. The lesion completely regressed after 38 days, and the patient is under follow-up.