Abstract
Non-Ulcer-Dyspepsia (NUD) is defined by The Rome III criteria as a chronic or recurrent epigastric pain within the last 3 months and an onset of symptoms at least 6 months prior to presentation. This disease has become a very common and costly condition, for the patient himself, and for the physician to diagnose it. It is not only the complexity of the pathophysiology that makes this disease a challenging diagnosis for the physician, it also the lack of testing strategies to approach a patient with this problem. In this review we will summarize the current universe of information of NUD, we will also cover the pathophysiology and the current guidelines for the evaluation and management, so the physician has a better sense of how to engage this common and difficult type of patients.
Highlights
Dyspepsia is a common problem clinician’s see daily in their clinics
Various reports suggest that the percentage of patients with an organic cause of dyspepsia range from 25-33% while 67-75% does not have a clear etiology
This paper will review the current definitions of non-ulcer dyspepsia (NUD), pathophysiology, and guidelines for evaluation and management
Summary
When patients have a thorough evaluation and no plausible etiology is found to explain their affliction, a diagnosis of non -ulcer dyspepsia is often assigned to them. Various reports suggest that the percentage of patients with an organic cause of dyspepsia range from 25-33% while 67-75% does not have a clear etiology. This paper will review the current definitions of non-ulcer dyspepsia (NUD), pathophysiology, and guidelines for evaluation and management. Symptoms include ulcer-like dyspepsia; gastroparetic-like (nausea, early satiety, and post-prandial pain), and undifferentiated.
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