Abstract
Aim: Cadmium is an important risk factor for cardiovascular disease (CVD). However, the underlying mechanism(s) are unclear. Cadmium has been shown to increase proteoglycan synthesis in vitro. Because proteoglycans mediate a critical step in atherosclerosis by trapping apoB-containing lipoproteins in the artery wall, we hypothesized that cadmium can increase proteoglycan mediated LDL binding and thereby promote subendothelial LDL accumulation. Here we tested the hypothesis that cadmium enhances the subendothelial accumulation of atherogenic lipoproteins in the setting of intimal hyperplasia and modest hypercholesterolemia.
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