Non-toxic and biodegradable κ-carrageenan/ZnO hydrogel for adsorptive removal of norfloxacin: Optimization using response surface methodology

Abstract

Antibiotic resistance is increasing globally due to increased prescription and easy dispensing of antibiotic drugs universally. Hence, to mitigate this effect, efficient, biodegradable, and non-toxic adsorbents are required to be developed. Carrageenan (CG), a natural polymer, having multiple functional groups, provides a backbone for crosslinking with borax and incorporation of ZnO nanoparticles that formed borax-cross-linked κ-carrageenan (CG/Bx/ZnO) hydrogel which is used for efficient adsorption of norfloxacin from water. Surface morphology of as-synthesized hydrogel revealed the rough surface, which was determined by FESEM. Surface area of CG/Bx/ZnO hydrogel was found to be 22.90 m2/g with 3.41 nm pore radius. Systematic batch adsorption studies revealed that 99.4 % removal efficiency could be achieved at a dosage level of 20 mg/L of norfloxacin with 10 mg of hydrogel at pH of 4 in 8 h at room temperature. Experimentally optimized key parameters affecting the overall efficiency of adsorption matched well with the results assessed from ANOVA using Box-Behnken composite design model. The adsorption process was well fitted with the pseudo-second-order model and Langmuir isotherm with 1282.05 mg/g adsorption capacity. Thermodynamic study results show that adsorption is spontaneous and endothermic. The CG/Bx/ZnO hydrogel demonstrated excellent repeatability with minimal loss in norfloxacin adsorption for seven cycles.