Non-toxic alveolar oxygen concentration without hypoxemia during apnoeic oxygenation: an experimental study

Abstract

Oxygenation without tidal breathing, i.e. apnoeic oxygenation in combination with extracorporeal carbon dioxide removal, might be an option in the treatment of acute respiratory failure. However, ventilation with 100% O₂, which is potentially toxic, is considered a prerequisite to ensure acceptable oxygenation. We hypothesized that trapping nitrogen (N₂) in the lungs before the start of apnoeic oxygenation would keep the alveolar O₂ at a non-toxic level and still maintain normoxaemia. The aim was to test whether a predicted N₂ concentration would agree with a measured concentration at the end of an apnoeic period. Seven anaesthetized, muscle relaxed, endotracheally intubated pigs (22-27 kg) were ventilated in a randomized order with an inspired fraction of O₂ 0.6 and 0.8 at two positive end-expiratory pressure levels (5 cm and 10 cm H₂O) before being connected to continuous positive airway pressure using 100% O₂ for apnoeic oxygenation. N₂ was measured before the start of and at the end of the 10-min apnoeic period. The predicted N₂ concentration was calculated from the initial N₂ concentration, the end-expiratory lung volume, and the anatomical dead space. The mean difference and standard deviation between measured and predicted N₂ concentration was -0.5 ± 2%, P = 0.587. No significant difference in the agreement between measured and predicted N₂ concentrations was seen in the four settings. This study indicates that it is possible to predict and keep alveolar N₂ concentration at a desired level and, thus, alveolar O₂ concentration at a non-toxic level during apnoeic oxygenation.