Abstract
The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N2/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time.
Highlights
Head and neck cancers are the fifth most common cancer type worldwide
Detroit 562 cells after plasma exposures of 0, 30, 60, and 90 s followed by a cultivation period of 48 h (Figure 1)
ROS concentration in medium increased with plasma exposure time
Summary
Head and neck cancers are the fifth most common cancer type worldwide. They can be categorized by the area where they originate from, e.g., lips, oral cavity (mouth), nasal cavity (inside the nose), paranasal sinuses, pharynx, or larynx. Most of these epithelial tumors are genomic alterations of head and neck squamous cell carcinoma (HNSCC) [1]. The possible causes include tobacco and alcohol consumption [2]. Different therapies exist [3], including surgery, radiotherapy, and chemotherapy, side effects are inevitable. The role that the inactivation of the tumor suppressor/suppressant gene p16 plays in the carcinogenesis of head and neck cancer has prognostic relevance [6,7]
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