Abstract
This report describes a dog with a clinical stage III oral malignant melanoma that was treated with complementary alternative medicine (CAM). The CAM included high temperature hyperthermia, dendritic cell therapy and lupeol injections. Surgery, radiation and chemotherapy were not performed. Two months after the start of treatment, the tumor disappeared and after six months, the follow-up examinations revealed no recurrence or metastasis of the tumor. Quality of life (QOL) of the dog was maintained; therefore, the application of CAM may be an effective treatment for canine oral malignant melanoma. The effective application of CAM has the potential to prolong life and maintain an excellent QOL for pets.
Highlights
In the field of veterinary medicine, canine melanoma is the most common type of malignant oral cancer [1]
Previous studies have reported a median survival time of 219‐273 days in cases of canine oral malignant melanoma, which were treated with surgery [2,3,4], with only 164 days in cases of clinical stage II or III canine oral malignant melanoma that were treated with surgery [5]
The present report describes a dog with stage III oral malignant melanoma, which was treated via non‐surgical complementary alternative medicine (CAM)
Summary
In the field of veterinary medicine, canine melanoma is the most common type of malignant oral cancer [1]. The present report describes a dog with stage III oral malignant melanoma, which was treated via non‐surgical complementary alternative medicine (CAM). With consent from the owner, application of CAM, including high temperature hyperthermia, injections of lupeol (Fig. 1), dendritic cell therapy and oral administration of extracts of Cordyceps sinensis (Monolis Inc., Saitama, Japan) were performed. 5 and 10 ml lupeol solution was injected topically and subcutaneously, respectively, and the original site was treated using a high temperature hyperthermia device (AMTC 200, AdMeTech Co., Ltd., Ehime, Japan). The application of CAM in the present study prolonged the life of a dog with oral malignant melanoma and, may be considered to be as effective as surgical and radiation therapy. Continued investigation into effective treatments is important to establish additional non‐surgical treatment methods for canine oral malignant melanoma
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