Abstract
Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract. IBD is characterized by a chronic intestinal inflammatory process with various components contributing to the pathogenesis of the disease including environmental factors such as smoking or use of Non Steroidal Anti-Inflammatory Drugs (NSAIDS). NSAIDS are among the most commonly used medications for the treatment of various inflammatory conditions. The main factor limiting NSAIDS use is the concern for the development of gastrointestinal toxicity including mucosal injury. A possible association between the use of NSAIDS and the onset or relapse of IBD has been repeatedly suggested. This article will review the current concepts and evidence of the relationship between IBD and NSAIDS.
Highlights
Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract and consist mainly of Crohn's disease (CD) and Ulcerative colitis (UC)
Use of Non Steroidal Anti-Inflammatory Drugs (NSAIDS) was associated with relapse of IBD
NSAIDS are associated with hospitalizations for severe colitis in patient with IBD
Summary
Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract and consist mainly of Crohn's disease (CD) and Ulcerative colitis (UC). Two very important and prevalent extra intestinal complications are rheumatic manifestations such as arthralgias, peripheral arthritis or ankylosing spondilitis and osteoporosis with increased risk of fractures secondary to vitamin D and calcium deficiency and prolonged steroid use [2,3]. For both these complications, and for non IBD related pain, patients with IBD often seek relief in NSAIDS [4,5]. NSAIDS may cause a non specific type of colitis and small intestinal inflammation with associated complications of chronic blood or protein loss [8]. Lack of controlled prospective trials, make it difficult to draw definite conclusions [4,11]
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