Abstract
AbstractAimTo describe the role of non‐steroidal anti‐inflammatory drugs (NSAIDs) in the management of pain after oral surgery.Materials and methodsA review of the literature describing the pharmacokinetics, benefits and harms of NSAIDs in terms of systematic review evidence, interactions, use in children, pregnancy and breastfeeding.ResultsTwelve Cochrane reviews were identified describing the efficacy of NSAIDs for pain after oral surgery. Ibuprofen 400 mg is an effective analgesic [number needed to treat (NNT) = 2.3 in tablet form and 1.8 in soluble form]. Cyclooxygenase‐2 (COX‐2)‐selective NSAIDs also demonstrate low NNTs, based on smaller studies of post‐operative pain. There is association with gastrointestinal, cardiovascular and renal adverse effects.ConclusionsNSAIDs are effective analgesics for moderate pain after oral surgery. The routine use of COX‐2‐selective NSAIDs is not recommended. Careful patient selection is important.
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