Abstract
Current paradigms hold that lung carcinomas arise from a pleuripotent stem cell that is capable of differentiation into one or several histologic cell types. These paradigms suggest that lung tumor cell ontology is determined by the consequences of gene transcriptional activation and/or repression that recapitulates events that are important in embryonic lung development. We examined the relationship of non-small cell lung cancer (NSCLC) gene profiles with lung development.
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