Non Significant Difference in Parathyroid Hormone, Calcium or Phosphat Levels Inpatients with Chronic Kidney Disease on Conservative or Replacement Therapeutic Modalities

Abstract

Background: Chronic Kidney Disease is defined as abnormalities of kidney structure and function present for more than 3 months , mineral changes can occur early in chronic renal diseasemainly phosphate, calcium hemostasis and secondary hyperparathyroidism Objectives: Determine the levels of serum calcium, phosphate, alkaline phosphatase, parathyroid hormone and vit D3. In chronic renal failurr and evaluate if Therese any significant difference for those on HD and on conservative treatment Methods: A cross sectional study was carried out among 150 uremic patients on conservative treatment or on haemodialysis. Take a full history from patents,full examination and proper investigation by using automated clinical chemistry analyser (Cobas integra 400 plus). Serum parathyroid hormone (PTH) and vit D3 by ELISA(Cobas e 400). Results: A total number of 150 patients with CKD in medical department and ibn_sina dialysis center at Baquba teaching hospital was investigated. The mean parathyroid hormone level was 144.87pg/ ml, An increase in PTH level above normal occurred in 41.34% of these patients, and 1.33% having hypoparathyroidisim,and 57.33% of them are normal. Hypocalcemia was found in 52.07% of patients,1.33% have hypercalcemia and 46.6% was associated with normal serum calcium level. Age compared to those with normal serum calcium levels. majority of patients had high serum phosphate levels(54.6%). And normal phosphate level in 40% while the hypophosphatemia result 5.33% and mean phosphate level is 2.3%mmol/l. Total serum protein mean is 61.51, a 37.4% of them had hypoproteinemia and 62.6% of them had normal serum protein. Also in our results show 97.33% of uremic patients have low vit D.Conclusion: the current study demonstrated that most uremic patients on conservative treatment and on haemodialysis having hyperparathyroidisim, hypocalcemia, hyperphosphatemia, hypoalbuminemia and low level of vit D.