Abstract
BackgroundChronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data.MethodsA literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg’ and Egger’s test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant.ResultsFive studies were identified in diverse ethnical groups with 1425 participants. The − 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg’s test and the linear regression Egger’s test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic.ConclusionsThis meta-analysis showed a non-significant association between − 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.
Highlights
Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth
Periodontitis is characterized as a clinical condition caused by accumulative dental plaque in periodontium and host-immune response with tissue damage resulting in possible teeth loss [1]
This cytokine is involved in both induction as well as termination of immune response [12] which IL-2 may promote the suppression of inflammation due to the T cells regulation [13]
Summary
Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Periodontitis is characterized as a clinical condition caused by accumulative dental plaque in periodontium and host-immune response with tissue damage resulting in possible teeth loss [1]. Several factors are involved in periodontitis development and progression from poor oral hygiene [8] to specific bacterial species in subgingival region [9] or even genetic factors in inflammatory mediators [10, 11]. Into the diverse molecules involved in host-immune response during infections or inflammation there is the interleukin (IL)-2. This cytokine is involved in both induction as well as termination of immune response [12] which IL-2 may promote the suppression of inflammation due to the T cells regulation [13]. The therapy by lowdose IL-2 or the recombinant form of IL-2 was observed as an effective approach to autoimmune conditions and inflammatory diseases [14] as well as the suppression of tumor growth in pancreatic cancer [15]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
