Abstract
Interlobular pausity (ILP) is a disease characterized lower cholestatic chanels as well as hepatocellular giant cell transformation or/and fibrosis. A 14 year-old boy was referred us for itching, jaundice and weight loss for 3 months. On examination, both sclera were icteric. Laboratory analysis revealed alanin aminotransferase 178 IU, aspartat amino transferase 89 IU, total/direct bilirubine:5.5/3.9 mg/dl, anti Hepatitis A Virus IgA and IgG negative, HBs Ag negative, anti HBs pozitive, anti HCV negative, AntiHIV negative, antinuclear antibody negative, anti double strand DNA negative, anti smooth muscle antibody negative, anti mitechondrial antibody negative and anti liver kidney antibody negative. Copper in 24 hour urine and seruloplasmine were normal. Liver biopsy showed lower interlobular cholestatic chanels and hepatocellular giant cell transformation. Phsycians should not delay for liver biopsy to diagnosis of interlobular pausity in adolescents with cholestatic signs if there is no primary disease for cholestasis.
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