Abstract
Non selective beta-blockers (NSBBs) have been used for decades in patients with liver cirrhosis to reduce portal pressure and the risk for portal hypertensive bleeding (1-3). International guidelines recommend NSBB as primary and secondary prophylaxis for variceal bleeding in cirrhosis (4). Patients with liver cirrhosis and portal hypertension have a distinct pathophysiological feature dominated by a hyperdynamic circulation (5).
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