Abstract
The non-random segregation of the sister chromatids of differentiating cells at mitosis is hypothesized. In a cell with n chromosomes, DNA replication results in n pairs of chromatids that must be segretated to daughter cells via one of 2 n modes. In only one of these 2 n modes do all of the oldest/newest parental DNA strands segregate togehter. It is our hypothesis that the segregation mode employed by the parental cell is fully non-random. The design of a system that can control this segregation is presented. In this control system, cell type specific segregation patterns will be dependent upon the use/non-use of potential replicative origins. As a consequence of controlled segregation, sister chromatid exchanges will, by their mis-segregatioe nature, engender abnormal cell types. Experimental data in the literature is re-interpreted in the light of this hypothesis.
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