Abstract
IntroductionThe non-motor symptoms (NMSs) in Parkinson’s disease (PD) patients have greater effects on their quality of life compared to the motor symptoms; however, they are under-recognized.The aimThe study aims to evaluate the prevalence and severity of NMS in newly diagnosed PD patients in Tanta University hospitals.Patients and methodsThe study included 41 newly diagnosed PD patients. All patients were screened for NMS by the non-motor symptoms questionnaire (NMS-Quest). According to the NMS-Quest response, patients were further evaluated by Sialorrhea Clinical Scale for PD (SCS-PD), Scales for Outcomes in Parkinson’s disease for Autonomic symptoms (SCOPA-AUT), Rome III Questionnaire, Nocturnal voiding and Sleep-Interruptions Questionnaire, Brief Pain Inventory, Montreal Cognitive Assessment (MoCA), Scale for Evaluation of Neuropsychiatric Disorders in Parkinson’s Disease (SEND-PD), Pittsburgh Sleep Quality Index (PSQI), and questionnaires based upon the International Restless Legs Study Group criteria.The resultsThe study included 22 female and 19 male patients; the duration of illness was 2.7 ± 2.08 years. Constipation was the most common symptoms as it was present in 73.1% in the studied patients; 61% suffered loss of sexual interest. 47.5% of patients had depressive symptoms. Sleep disturbance was present in 36.6% of the patients. Anxiety was reported by 30% of the patients.ConclusionAll newly diagnosed PD patients suffered one or more NMSs; constipation was the most frequent followed by sexual dysfunction, depressive symptoms, and sleep disturbance, while pain, sialorrhea, and restless leg were the least reported.
Highlights
The non-motor symptoms (NMSs) in Parkinson’s disease (PD) patients have greater effects on their quality of life compared to the motor symptoms; they are under-recognized.The aim: The study aims to evaluate the prevalence and severity of NMS in newly diagnosed PD patients in Tanta University hospitals
All newly diagnosed PD patients suffered one or more NMSs; constipation was the most frequent followed by sexual dysfunction, depressive symptoms, and sleep disturbance, while pain, sialorrhea, and restless leg were the least reported
Patients with PD experience a wide range of non-motor symptoms (NMSs) which manifest as cognitive, neuropsychiatric, autonomic, and sensory disturbances; they worsen with disease progression and represent the major determinants of their independency loss [3]
Summary
The non-motor symptoms (NMSs) in Parkinson’s disease (PD) patients have greater effects on their quality of life compared to the motor symptoms; they are under-recognized.The aim: The study aims to evaluate the prevalence and severity of NMS in newly diagnosed PD patients in Tanta University hospitals. NMSs were present in 96.4% of the studied patients by Khedr et al [4] with mood and cognitive dysfunction as the most common followed by sleep disturbance and fatigue. Egyptian study by Shalash et al [5], all studied patients had one or more NMSs, with the most common were fatigue and sleep disturbance. Anosmia, sleep disturbance, gastrointestinal function, and mood changes may precede the onset of motor manifestation of PD by 5 or more years [6]. They are not identified by neurologists in over 50% of consultations, and sleep disturbance is not recognized in over 40% of PD patients. Drug-naive PD patients are an ideal population to study the differences in presentation of NMS [7]
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More From: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
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