Non-invasive treatment of uterine fibroids using MR guided high intensity focused ultrasound: results on quality of life, non-perfused volume ratio and size reduction over 12 months

Federica Ciolina,Fulvio Zaccagna,Carlo Catalano,Beatrice Marincola,Carola Palla,Alessandro Napoli,Fabrizio Boni,Luca Bertaccini,Vincenzo Noce

doi:10.1186/2050-5736-2-s1-a18

Federica Ciolina, Fulvio Zaccagna + Show 7 more

Open Access

https://doi.org/10.1186/2050-5736-2-s1-a18

Copy DOI

Abstract

Materials and method 110 leiomyomas in 98 women (average age 39,3 years) were treated with MRI-guided focused ultrasound (MRgFUS). The treatment is carried out using the ablative properties of the HIFU system under 3T MRI guide. Symptoms (e.g. menorrhagia, pelvic pain) were scored using Severity Score (SS) and quality of life was determined using the UFS-QOL score. Pre-treatment measurementes of leiomyoma volume were obtained by MR images. Immediately after treatment, Non-perfused Volume (NPV) was calculated from T1-w contrastenhanced MR sequences. The average volume of treated fibroids was 90.27 ± 90.4 mm3. Follow-up images were obtained at 3 and 12 months after treatment and served to determine leiomyoma shrinkage. Qualitative and quantitative relations between fibroid volume, NPV ratio at treatment, and 12-month shrinkage were measured.

Highlights

To evaluate the efficacy of MR guided acoustic ablation in symptoms relief and volume reduction over time
MRI-guided focused ultrasound (MRgFUS) treated patients demonstrated a significant change in USF-QoL score: mean Severity Score (SS) score values were 48.6 ± 13.4, 25.1 ± 8.9 and 19,3± 6.8
Fibroids volume changed from 90.27±90.4 mm3 to 54 ± 66.1 mm3

Summary

Introduction

To evaluate the efficacy of MR guided acoustic ablation in symptoms relief and volume reduction over time. Non-invasive treatment of uterine fibroids using MR guided high intensity focused ultrasound: results on quality of life, non-perfused volume ratio and size reduction over 12 months Federica Ciolina*, Fabrizio Boni, Fulvio Zaccagna, Luca Bertaccini, Beatrice Cavallo Marincola, Vincenzo Noce, Carola Palla, Alessandro Napoli, Carlo Catalano From 2nd European Symposium on Focused Ultrasound Therapy Rome, Italy. Purpose To evaluate the efficacy of MR guided acoustic ablation in symptoms relief and volume reduction over time.

Results

Conclusion