Abstract
Thoracic electrical bioimpedance (TEB) and transthoracic echocardiography (TTE) are non-invasive methods to estimate stroke volume (SV) and cardiac output (CO). Thoracic electrical bioimpedance is not in widespread clinical use with reports of inaccurate cardiac output estimation compared to invasive monitors, particularly in non-healthy populations. We explore its use as a trend monitor by comparing it against thoracic echocardiography in fifteen healthy volunteers undergoing two physical challenges designed to vary cardiac output. Of all paired values, 54.6% showed gross trend agreement and only 1.9% showed direct disagreement between the two monitors. Our results show thoracic bioimpedance may have a role as a non-invasive cardiac output trend monitor in healthy volunteer studies.
Highlights
Thoracic electrical bioimpedance (TEB) cardiac output (CO) measurement has been validated against thermodilution measurements in healthy volunteers [1] but has been reported to be unreliable in clinical settings and is not in widespread clinical use [2]
We describe the agreement in stroke volume (SV) measurements between TEB and transthoracic echocardiography (TTE)
Our study results show a clear trend agreement between SV changes detected by TTE and TEB in healthy subjects
Summary
Thoracic electrical bioimpedance (TEB) cardiac output (CO) measurement has been validated against thermodilution measurements in healthy volunteers [1] but has been reported to be unreliable in clinical settings and is not in widespread clinical use [2]. We designed a healthy volunteer study primarily to compare video-derived proxies for CO with TEB and TTE. These reference methods were chosen for their non-invasive nature and their validated performance in healthy subjects against invasive monitors. If TEB showed good agreement with TTE, its ability to provide continuous SV assessment following TTE assessment and calibration would be useful in healthy volunteer trial settings. It may provide justification for further studies exploring TEB as a monitor of SV changes in other populations
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