Abstract
Repair of soft tissue defects of the lips, as seen in complex maxillofacial injuries and post-ablative defects, requires pre-vascularized multi-tissue composite grafts. Protocols for fabrication of human exvivo produced oral mucosal equivalents (EVPOME) composed of epithelial cells and a dermal equivalent are now available to create prelaminated flaps for grafting in patients for lip reconstruction. However, invivo assessment of vascularization of the buried prelaminated flaps remains clinically challenging. Here, we use diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) to non-invasively quantify longitudinal changes in the vascular saturation and blood-flow within EVPOME grafts, and explore the utility of these optical techniques for assessing vascularization of implanted grafts.
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