Abstract
Management of unexplained repeated implantation failure (RIF) patients is a major challenge in ART. It is well known that successful implantation is dependent on the intricate dialogue between a viable embryo and a receptive endometrium. On the maternal side, specific property changes in adhesion need to occur for blastocyst attachment, as well as tight regulation of signaling pathways in the microenvironment of the invading embryo. The aim of this study was to examine ahead of embryo transfer the uterine fluid milieu, including the microRNAome and proteome, in association with implantation outcome.
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