Non Invasive Brain Stimulation Study Based on Ischemic Stroke Patients.

Abstract

Non-invasive brain stimulation (NIBS) methods are progressively used as neuromodulator and showing optimistic potential for medical practice. In present study experimental NIRS-tDCS raw dataset of twenty-two sub-acute ischemic stroke patients has been used to explore the significant variation in measured NIRS signal namely cerebral oxygenation, oxy-hemoglobin and deoxy-hemoglobin before and after tDCS. Pearson correlation statistical method is used to determine the strength and relationship between hemodynamic responses. The negative correlation has been shown between oxy-hemoglobin and deoxy-hemoglobin before and after tDCS at 99% confidence interval (P<; 0.01). One sample t-test is used to determine the pre to post tDCS significant change in regional cerebral oxygenation, oxy-hemoglobin and deoxy-hemoglobin independently at 99% confidence interval (P<; 0.01). On the basis of significant change in the NIRS measurement parameters (HbO2, Hb and rSO2) the healthy and lesioned hemisphere of patients suffering from sub-acute ischemic stroke have been classified. A significant increase in pre to post rSO2 has been found in the healthy hemispheres of patients. For the lesioned hemisphere, the two cases were found. One is due to the decrease in rSO2 after tDCS and significant change from pre to post rSO2. The second is negligible pre to post change in the rSO2 and insignificant variation in rSO2.