Abstract
Right heart catheterization remains necessary for the diagnosis of pulmonary hypertension and, therefore, for the prognostic evaluation of patients with chronic heart failure. The non-invaSive Assessment of Pulmonary vasculoPathy in Heart failure (SAPPHIRE) study was designed to assess the feasibility and prognostic relevance of a non-invasive evaluation of the pulmonary artery vasculature in patients with heart failure and pulmonary hypertension. Patients will undergo a right heart catheterization, cardiac resonance imaging, and a pulmonary function test in order to identify structural and functional parameters allowing the identification of combined pre- and postcapillary pulmonary hypertension, and correlate these findings with the hemodynamic data.
Highlights
Pulmonary hypertension (PH) is a common complication of chronic heart failure (HF)associated with worse outcomes and increased mortality [1]
This study is based on the hypothesis that Magnetic resonance imaging (MRI) and pulmonary functional test (PFT)
Pulmonary hypertension due to HF is a marker of poor prognosis owing to a higher risk of morbidity and mortality [1,3,4]
Summary
Pulmonary hypertension (PH) is a common complication of chronic heart failure (HF)associated with worse outcomes and increased mortality [1]. Pulmonary hypertension (PH) is a common complication of chronic heart failure (HF). Its presence is a marker of poor prognosis in patients with HF [2,3]. It begins as a passive process due to congestion as a result of both systolic and diastolic left ventricular dysfunction. Elevated pulmonary venous pressures induce structural changes in the pulmonary vasculature, which may become irreversible, increasing pulmonary vascular resistance (PVR) and the risk of right ventricular failure [4]. An invasive approach through right heart catheterization (RHC) remains necessary for the diagnosis and classification of PH, as well as to determine its reversibility.
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