NON-INTERVENTIONAL WEIGHT CHANGES AFFECT SYSTOLIC BLOOD PRESSURE IN NORMOTENSIVE INDIVIDUALS

Abstract

Objective: The association between obesity and hypertension is well established. Weight loss has been shown to reduce blood pressure (BP) among hypertensive patients. Nevertheless, the effect of weight changes on BP in normotensive individuals is less clear. We explored the association between non-interventional weight alterations and BP changes in a large cohort of normotensive adults. Design and method: a retrospective analysis of normotensive individuals, between 2010–2018. All weight changes were non-interventional. Body mass index (BMI) and BP were measured annually. Patients were divided according to the change in BMI between visits: reduction of more than 5% (’large reduction’), between 2.5–5% (’moderate reduction’), reduction of less than 2.5% or elevation of less than 2.5% (’unchanged’), elevation between 2.5–5% (’moderate increase’) and elevation of more than 5% (’large increase’). The primary outcome was the change in systolic BP (SBP) between the visits. Results: The final analysis included 8,723 individuals. 20% of the subjects reduced their BMI by at least 2.5% and 24.5% increased their BMI by more than 2.5%. ’High reduction’ inferred an absolute decrease of 3.6 mmHg in SBP, while ’large increase’ resulted in an absolute increase of 1.9 mmHg in SBP. The proportion of individuals with at least 10 mmHg decrease in SBP progressively declined according to the relative decrease in BMI, and the proportion of patients with at least 10 mmHg increase in SBP progressively increased. This effect was more pronounced in individuals with higher baseline SBP. Conclusions: Among normotensive adults, modest non-interventional weight changes may have significant effects on SBP.