Non-inflammatory infestive benign acanthotic papule of the skin: Histopathological evidence

Abstract

We report histopathological evidence of mycoplasma infestation of the squamous epithelium presenting non-inflammatory benign acanthotic papule of the skin in an adult male, not reported in the previous literature. Sections showed hyper-chromatic basal layer with marked acanthosis and inclusions with nucleic body surrounded by cytoplasm devoid of cell wall. Histopathological evidence was diagnostic of mycoplasma infested non-inflammatory benign acanthotic papule of the skin. Nuclear and cytoplasmic microbial inclusions in the epithelial cells, and keratinocytic and cytolytic changes could be the source of signals to the basal strata for benign epitheliomatous proliferation, giving rise to non-inflammatory benign acanthotic papule.