Abstract
Hypersplenism and non-hypersplenism factors, either alone or in combination, can cause peripheral cytopenias in patients with cirrhotic portal hypertension. Although non-hypersplenism factors account for only a small proportion of patients, they do exist. When peripheral cytopenias do not improve, or fail to improve adquately, or even become worse after splenectomy in these patients, non-hypersplenism factors should be considered. This review aims to provide an overview of non-hypersplenism factors.
Highlights
Hypersplenism Causes Non-hypersplenism Causes Toxic effects of viruses on bone marrowPeripheral cytopenias refer to the lower-than-normal counts of circulating leukocytes, erythrocytes, and platelets
Peripheral cytopenias can be caused by both hypersplenism and non-hypersplenism factors
Peripheral cytopenias were previously thought to be caused by hypersplenism alone in patients with cirrhotic portal hypertension [5,6,7], and decreased blood cells levels would return to normal after splenectomy
Summary
Hypersplenism Causes Non-hypersplenism Causes Toxic effects of viruses on bone marrowPeripheral cytopenias refer to the lower-than-normal counts of circulating leukocytes, erythrocytes, and platelets. These factors, either alone or in combination, can cause peripheral cytopenias in patients with cirrhotic portal hypertension. Peripheral cytopenias were previously thought to be caused by hypersplenism alone in patients with cirrhotic portal hypertension [5,6,7], and decreased blood cells levels would return to normal after splenectomy.
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