Abstract
There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to Homo sapiens assures that much better translatability of research outcomes from model studies involving human diseases can be achieved than from those generated with other pre-clinical systems. Our group and others used during past two decades NHPs in research directed towards viral and autoimmune disorders of the gastrointestinal tract. This review summarizes progress made in the area of enteric viral infections including its applicability to human disease.
Highlights
The use of non-human primates (NHP) in biomedical research can be traced to early 20th century and discovery of ABO blood groups [1]
Several of the NHP species, predominantly those kept in captivity, helped to facilitate progress in various biomedical areas including behavioral sciences, genetics/genomics, cancer, neuroscience, HIV/AIDS, cardiovascular and respiratory disorders, regenerative medicine, endocrinology, aging, immune-mediated disorders, and infectious diseases
According to epidemiological surveys conducted during recent years by our group with participation of three National Primate Research Centers and three zoos in the U.S, a seasonal incidence of viral diarrhea-associated disease exists at captive NHP colonies [5,8]
Summary
The use of NHPs in biomedical research can be traced to early 20th century and discovery of ABO blood groups [1]. There are emerging research areas exploiting those features of NHP models that cannot be duplicated in vitro or with alternative in vivo systems. In this short review, the human health-relevant enteric viruses of NHP host origin are Viruses. The in vitro basic function and information these models can generate in a cascade of events starting from: (A) the in investigation;. With continuous improvement of primate-specific diagnostic assays and increased demand for disease-free primates in biomedical research, some primate centers raise expanded SPF colonies with voluntary diagnostic screening for following eight pathogens: (5) Simian foamy virus (SFV); (6) Primate cytomegalovirus (CMV); (7) Rhesus rhadinovirus (RRV); (8) Simian varicella virus (SVV); (9) Simian vacuolating virus. 40 (SV40); (10) Lymphocytic choriomeningitis virus (LCV); (11) Measles virus; and (12) Burkholderia psedomallei (http://www2.tulane.edu/tnprc/microbiology/resources/)
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