Abstract
A 54-year-old female patient presented to a dental office with a chief complaint of pain in her palate. Intraoral physical examination revealed a 2-cm local swelling with a small, centered ulceration and dilated superficial capillaries in the left posterior palatal area. Cone beam computed tomography did not show bone destruction. An incisional biopsy was performed and the histopathologic exam was inconclusive. Immunohistochemistry was positive for Ki-67 marker; co-expression of CD45, CD20, BCL-2, and BCL-6 associated with a high proliferative index of Ki-67 established a diagnosis of diffuse large B-cell lymphoma. Positron emission tomography revealed the involvement of the hard and soft palate, palatine tonsil, cervical and axillary lymph nodes, and inguinal area. The palatal lesion showed very rapid growth, affecting the underlying bone, causing extensive destruction and leading to a buccosinusal communication in a short period of time. An acrylic palatal obturator was installed to improve the patient's quality of life during oncological treatment.
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