Non-Hodgkin's Lymphoma Mimicking Gynecologic Malignancies of the Uterine Corpus, Cervix, and Vagina: A Report of Three Cases

Abstract

Background: Primary lymphomas affecting the female genital tract are uncommon; however, evidence is accumulating that these tumors are underdiagnosed, both because they are unexpected in these sites and because they are misdiagnosed as others lesions or malignant tumors. Cases: Three cases of extranodal non-Hodgkin's lymphoma presenting with signs and symptoms consistent with cancer of the lower genital tract (uterine corpus, uterine cervix, or vagina) and lacking the ‘‘B’’ symptoms often associated with systemic lymphoma such as fever, weight loss, night sweats, and fatigue. The clinicopathologic presentation, staging, and different treatments are presented. The associated literature is also reviewed. Results: All three patients were given chemotherapy and have remained well as of the time this article was written. Conclusions: An accurate diagnosis leads to the appropriate therapy, and improves prognosis. Therefore, it is important to include pelvic lymphomas in the differential diagnosis of uterine, cervical, or vaginal cancer in some patients. (J GYNECOL SURG 28:158)