Abstract
The direct hydroxylation of aliphatic carbon atoms is a challenging task in organic chemistry. Nature's unique ability to solve this problem by using non-heme iron hydroxylases was applied to the stereospecific synthesis of the medically important compound L-threo-hydroxyaspartic acid. We switched the substrate specificity of a hydroxylase (AsnO) from L-asparagine to L-aspartic acid by a simple side chain swap in the substrate binding pocket.
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