Abstract
Six non-glycosidic iridoids, i.e. (1 R,4 S,4a S,7 S,7a S)-7-hydroxyl-4-hydroxy- methyl-7-methyl-1-methoxyl-1,4,4a,7a-tetrahydrocyclopenta[ e]pyran-3-one ( 1), (1 S,4 R,4a S,7 S,7a S)-7-hydroxyl-4-hydroxymethyl-7-methyl-1-methoxyl-1,4,4a,7a-tetrahydrocyclopenta[ e]pyran-3-one ( 2), (1 R,4 R,4a S,7 S,7a S)-7-hydroxyl-4-hydroxy-methyl-7-methyl-1-methoxyl-1,4,4a,7a-tetrahydrocyclopenta[ e]pyran-3-one ( 3), (1 R, 4 R, 4a S, 7a S)-4,7-dihydroxymethyl-1-methoxyl-1,4,4a,7a-tetrahydrocyclopenta-6-ene[ e]pyran-3-one ( 4), (1 R, 4 R, 4a S, 7a S)-4,7-dihydroxymethyl-1-hydroxyl-1,4,4a, 7a-tetrahydrocyclopenta-6-ene[ e]pyran-3-one ( 5), (1 R, 4 S, 4a S, 7a S)-4,7-dihydroxy-methyl-1-methoxyl-1,4,4a,7a-tetrahydrocyclopenta-6-ene[ e]pyran-3-one ( 6), as well as five known non-glycosidic iridoids mussaenin A ( 7), gardendiol ( 8), isoboonein ( 9), 4-epi-alyxialactone ( 10) and rehmaglutin D ( 11) have been isolated from the Chinese medicinal plant Cymbaria mongolica. Their structures were elucidated by spectroscopic methods. These compounds exhibit significant antitumor and antibacterial activity.
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