Abstract
Due to appearance of pests resistance and negative effects on ecological environment, it is high desirable to explore candidate pesticides from non-food bioactive products. Here a series of succinic acid derivatives of podophyllotoxin derived from the renewable Sinopodophyllum hexandrum, were semisynthesized for pest management. The spatial configurations of three derivatives were determined by X-ray crystallography. Compounds IIIc and IIId (> 2-fold of podophyllotoxin) exhibited the most pronounced insecticidal activity. Compounds 5, IIIa and IIIb displayed > 11-fold promising acaricidal activity of podophyllotoxin. Especially compound IIIb showed the pronounced insecticidal and acaricidal activities. It will pave the way for further structural modifications and application of podophyllotoxins as potentially renewable botanical pesticidal agents in crop protection.
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