Abstract
BackgroundThe majority of pregnant women present an increase in lipids. To investigate the influence of the non-fasting state in the lipid and lipoprotein profile in pregnancy, we have aimed to assess the dynamic change of serum lipid and lipoprotein profile with serum glucose in pregnancy to contrast the differences between fasting and non-fasting state.MethodsForty-five pregnant women and 41 controls were included in our study. All serum samples were assayed for TC, TG, HDL-C, LDL-C, ApoB, ApoA-1, Lp(a), sdLDL, and Glu concentrations. The comparison between pregnant women and controls (fasting and 2 h after breakfast), differences of these measurement results at three point-in-time, the associations between the concentrations of serum lipid and some maternal and fetus characteristics was conducted with statistical analysis.ResultsExcept Glu (p < 0.001), there were no significant differences of all lipids between three point-in-time in pregnant women (p > 0.1). The statistically higher levels were found in fasting TC (p = 0.003), TG (p = 0.019), LDL-C (p = 0.002), ApoB (p = 0.001), ApoA1 (p = 0.013) and sdLDL (p < 0.001) of pregnant women compared with controls. Besides, the statistically significances were also found in 2-h TC (p = 0.001), LDL-C (p = 0.001), ApoB (p < 0.001), Glu (p = 0.013), ApoA-1 (p = 0.009) and sdLDL (p < 0.001) of pregnant women compared with controls. Otherwise, in non-fasting status (2 h after breakfast), pregnancy complication was relevant to TC (p = 0.041), HDL-C (p = 0.014), Glu (p = 0.004). Delivery mode was relevant to TC (p = 0.012), HDL-C (p = 0.013), LDL-C (p = 0.026), ApoA-1 (p = 0.012), and sdLDL (p = 0.044). BMI was relevant to TG (p = 0.027).ConclusionWe have suggested the non-fasting lipids detection can be used for estimate lipid metabolism in pregnant women.
Highlights
Pregnancy is characteristic of physiological metabolic adaptations [1, 2]
The statistically higher levels were found in fasting total cholesterol (TC) (p = 0.003), TG (p = 0.019), low density lipoproteins (LDL)-C (p = 0.002), apolipoprotein B (ApoB) (p = 0.001), ApoA1 (p = 0.013) and small dense LDL (sdLDL) (p < 0.001) of pregnant women compared with controls (Fig. 1)
The statistically significances were found in 2-h TC (p = 0.001), LDL-C (p = 0.001), ApoB (p < 0.001), Glu (p = 0.013), apolipoprotein A-1 (ApoA-1) (p = 0.009) and sdLDL (p < 0.001) of pregnant women compared with controls (Fig. 1)
Summary
Pregnant women experience peripheral insulin resistance, and levels of hormones increase compared with the non-pregnant state [3, 4]. All serum lipid fractions progressively increase [5, 6]. These metabolic adaptations are essential to support adequate fetal growth and development [1, 2]. The change of serum lipid fractions is physiological and results from increased insulin resistance, lipoprotein synthesis and lipolysis in adipose tissue which mobilize fats to serve as an energetic supply for fetal growth [7, 8]. The majority of pregnant women present an increase in lipids. To investigate the influence of the non-fasting state in the lipid and lipoprotein profile in pregnancy, we have aimed to assess the dynamic change of serum lipid and lipoprotein profile with serum glucose in pregnancy to contrast the differences between fasting and non-fasting state
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
