Non-fasting lipids and cardiovascular disease in those with and without diabetes in Alberta's Tomorrow Project: a prospective cohort study.

Abstract

Non-fasting remnant cholesterol (RC) is a novel marker of cardiovascular disease (CVD) risk, however data on this relationship in Canadians with diabetes (at high risk of CVD) is lacking. The objective of this analysis was to determine the relationship of RC with CVD in individuals with and without diabetes in the Alberta's Tomorrow Project (ATP) cohort. Non-fasting lipid data collected as part of the ATP was linked to administrative health records (October 2000 - March 2015) to ascertain incident CVD and prevalent diabetes. Participants without prevalent CVD or incident diabetes and who had complete, non-negative non-fasting lipid data collected with triglycerides <4.5mmol/L were included (n=13,631). The relationship between non-fasting RC and incident CVD diagnoses was assessed by Cox proportional hazards regression, after stratification by diabetes status. Participants were 69.8% women with a mean age of 61.6±9.7 years, and 6.5% had prevalent diabetes. Non-fasting RC was higher in participants with diabetes compared to those without (mean 0.94±0.41mmol/L vs. 0.77±0.38mmol/L, p<0.0001) and was associated with increased risk of incident CVD among those without diabetes (adjusted hazard ratio (aHR) 1.22, 95% CI 1.03-1.43, p=0.02). Although a similar trend was observed in participants with diabetes it did not reach statistical significance (aHR 1.31, 95% CI 0.84-2.05, p=0.23). Elevated non-fasting RC predicted increased CVD risk in middle and older-aged adults without diabetes; similar trends were observed in participants with diabetes and requires further testing in a larger sample.