Non-Enzymatic Electrochemical Detection for Uric Acid Based on a Glassy Carbon Electrode Modified With MOF-71

Abstract

The development of non-noble-metal sensing material for sensitive and selective detection of uric acid with a simple material synthesis technique has not been frequently reported in recent years. Taking advantage of the unique properties of highly porous materials of Metal-Organic Frameworks, which incomparable in their structural diversity and tunability as well as their range of chemical and physical properties, open up a chance for developing novel nanomaterial for electrochemical sensor applications. In this article, we evaluated MOF-71 as a sensing material on a glassy carbon electrode (GCE) in a three-electrode system for electrochemical detection of uric acid. The MOF-71 was synthesized by a simple solvothermal method. Its structural characteristics that are examined by scanning electron microscopy and X-ray diffraction confirmed the successful formation of MOF-71. Cyclic voltammetry (CV) and differential pulse voltammetry DPV) analysis showed the successful uric acid detection in a phosphate buffer solution and showed good electrochemicalcatalytic activity toward uric acid. DPV was selected for the determination of uric acid with a sensitivity of 0.4811 mA.mM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1.</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , the detection range of 50.0-1000 μM, and detection limit of 15.61 μM at an S/N = 3.