Non‐enzymatic continuous glucose monitoring system

Abstract

A prominent field of study in biosensor development is the study of electric properties which provide valuable insight into the fluids contents. In this research, a non-enzymatic glucose sensor is fabricated, characterised, and employed. The developed device determines the effects of electrode surface area on sensing efficacy, the effects of glucose concentration on impedimetric response, and a real-time measurement of glucose concentration. Deviations throughout the entire glucose range are detected as an inverse of the impedance in the cell due to the inverse relationship of glucose concentration and charge transfer resistance. The continuous monitoring of glucose is demonstrated by a rapid device response over two iterations of glucose concentration in ascending order: 50 μM, 400 μM, and 3.2 mM. At a sustained frequency of 10 kHz, the result shows a stable impedimetric response of 1038, 752, and 688 kΩ, respectively. The validity of the device as a continuous glucose monitoring method is carried out by repeating the cycle and observing the response.