Abstract
In this study, a 1H nuclear magnetic resonance (NMR) method to quantify the alcohol content of alcohol-based hand sanitizers was developed and validated in non-deuterated solvent and unlocked mode conditions. Deionized water was used to prepare the solutions for the no-D method, which also matched the matrix of the samples. The generated integration areas were used to quantify the ethanol and isopropanol content of the sanitizer samples. The no-D method presented well-correlated calibration curves with a detection limit of 1.41% (v/v) and 2.61% (v/v) for isopropanol and ethanol, respectively. The experimental alcohol content in no-D conditions was compared to the results using the D2O method and was not significantly different (p > 0.05). Although there is no additional precautionary measure when handling D2O, non-deuterated solvents are more easily accessible, which makes a 1H NMR-based analysis more cost-effective.
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