Abstract
We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its alpha- crystalline form and the amount of A-IM in the smartFilms reduces. Both, alpha- and A-IM are preferred over the more common gamma- crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug.
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