Abstract
The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities. Expansion and refinement in the field of asymmetric organocatalysis have made possible the development of straightforward strategies that address these two requisites. In this review, we illustrate the current state-of-the-art in the field of spirooxindole synthesis through the use of non-covalent organocatalysis. We aim to provide a concise overview of very recent methods that allow to the isolation of unique, densely and diversified spirocyclic oxindole derivatives with high structural diversity via the use of cascade, tandem and domino processes.
Highlights
Heterocyclic compounds are found in a broad range of bioactive molecules, natural products, and drugs
Asymmetric organocatalysis has appeared as an appealing tool in order to prepare such compounds with rich structural diversity and complexity through cascade, tandem, and domino processes [7,8,9]
The aim of this review is to describe recent advances towards the stereocontrolled synthesis of strained spiro-quaternary stereocenters on the oxindole core through non-covalent organocatalysis [14,15,16]
Summary
Heterocyclic compounds are found in a broad range of bioactive molecules, natural products, and drugs. Several novel efficient strategies based on catalytic methods have been validated to date for the direct assessment of such scaffolds in an enantiopure fashion [1,2,3] In this context, spirocyclic oxindole derivatives have appeared as privileged structural motifs being part of a great number of synthetic and natural products displaying remarkable biological activities as well as useful biomedical applications (Figure 1) [4,5,6]. After a quick overview about the Cinchona alkaloids (Section 1), Far to be exhaustive and comprehensive, the current review is divided according to the most the synthetic elaborations of thesethe natural-occurring are going to be Farsubsequent to be exhaustive and comprehensive, current revieworganocatalysts is divided according to the most employed class of catalysts.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
