Abstract
Multiple sclerosis (MS) is an early onset chronic neurological condition in adults characterized by inflammation, demyelination, gliosis, and axonal loss in the central nervous system. The pathological cause of MS is complex and includes both genetic and environmental factors. Non-protein-coding RNAs (ncRNAs), specifically miRNAs and lncRNAs, are important regulators of various biological processes. Over the past decade, many studies have investigated both miRNAs and lncRNAs in patients with MS. Since then, insightful knowledge has been gained in this field. Here, we review the role of miRNAs and lncRNAs in MS pathogenesis and discuss their implications for diagnosis and treatment.
Highlights
Multiple sclerosis (MS) is a chronic inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS) (Thompson et al, 2018)
The pathological hallmark of MS is the accumulation of focal plaques, which are areas of demyelination along with infiltration of immune cells found throughout the CNS (Mahad et al, 2015)
Almost 85% of patients typically present with relapsing-remitting MS (RRMS), which is characterized by episodes of disability, followed by a period of recovery (Confavreux and Vukusic, 2014; Mahad et al, 2015; Thompson et al, 2018)
Summary
Multiple sclerosis (MS) is a chronic inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS) (Thompson et al, 2018). Multiple studies have reported a repertoire of aberrantly expressed miRNAs in both the immune and CNS cells of MS patients. DYSREGULATION OF miRNA IN THE IMMUNE CELLS OF MULTIPLE SCLEROSIS PATIENTS
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