Year-end Sale % OFF 
Abstract
This review will focus on the current state of knowledge regarding non-coding RNAs (ncRNA) in stroke and neuroprotection. There will be a brief introduction to microRNAs (miRNA), long ncRNAs (lncRNA), and piwi-interacting RNAs (piRNA), followed by evidence for the regulation of ncRNAs in ischemia. This review will also discuss the effect of neuroprotection induced by a sublethal duration of ischemia or other stimuli given before a stroke (preconditioning) on miRNA expression and the role of miRNAs in preconditioning-induced neuroprotection. Experimental manipulation of miRNAs and/or their targets to induce pre- or post-stroke protection will also be presented, as well as discussion on miRNA responses to current post-stroke therapies. This review will conclude with a brief discussion of future directions for ncRNAs studies in stroke, such as new approaches to model complex ncRNA datasets, challenges in ncRNA studies, and the impact of extracellular RNAs on human diseases such as stroke.
Highlights
Despite advances in preclinical studies that have established mechanisms of cell death in brain ischemia and identified potential strategies to prevent or treat brain injury following stroke, few of these advances have successfully translated into clinical practice
The goal of this review was to present the current state of knowledge regarding non-coding RNAs (ncRNA) and their role(s) in stroke and neuroprotection
The long non-coding RNAs (lncRNA) and piwi-interacting RNAs (piRNA) are certain to contribute to the setting of ischemia and neuroprotection, and there are several important future lines of investigation for all ncRNA studies
Summary
Despite advances in preclinical studies that have established mechanisms of cell death in brain ischemia and identified potential strategies to prevent or treat brain injury following stroke, few of these advances have successfully translated into clinical practice. This review will present the current state of knowledge regarding evidence for specific families of non-coding RNAs (ncRNA) in experimental stroke and neuroprotection: microRNAs (miRNA), long non-coding RNAs (lncRNA), and piwi-interacting RNAs (piRNA). This review will focus on three newer families of ncRNAs; [1] miRNAs that regulate post-transcriptional gene expression, largely by direct effects on mRNAs [13], [2] lncRNAs that can regulate transcription and translation, and act as epigenetic modifiers, and [3] piRNAs that largely exert effects on transcription and genomic maintenance. The reader is directed to a 2014 Frontiers in Cellular Neuroscience Research Topic entitled “Regulatory RNAs in the Nervous System” for comprehensive discussions regarding the biosynthesis and function of these ncRNAs, as well as a recent review entitled “Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury,” which beautifully www.frontiersin.org
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
