Abstract
Eukaryotic genomes are pervasively transcribed, producing both coding and non-coding RNAs (ncRNAs). ncRNAs are diverse and a critical family of biological molecules, yet much remains unknown regarding their functions and mechanisms of regulation. ATP-dependent nucleosome remodeling complexes, in modifying chromatin structure, play an important role in transcriptional regulation. Recent findings show that ncRNAs regulate nucleosome remodeler activities at many levels and that ncRNAs are regulatory targets of nucleosome remodelers. Further, a series of recent screens indicate this network of regulatory interactions is more expansive than previously appreciated. Here, we discuss currently described regulatory interactions between ncRNAs and nucleosome remodelers and contextualize their biological functions.
Highlights
Many cellular processes occur within the cell nucleus where access to the information encoded with genomic DNA is essential
On one side of this interaction are nucleosome remodelers, whose activity is required for non-coding RNA (ncRNA) expression in some instances but necessary for their suppression to maintain genomic stability in others
On the other side of this interaction are ncRNAs, indispensable to proper nucleosome remodeling targeting and complex composition yet serving as critical limiters for the functions of others
Summary
Many cellular processes occur within the cell nucleus where access to the information encoded with genomic DNA is essential. Eukaryotes have evolved several mechanisms to alter chromatin structure, including protein complexes [2], DNA modifications [3], post-translational histone modifications [4], and histone variants [4], which regulate chromatin accessibility for all DNA-templated processes. Due to advances in genomics and RNA-protein interaction probing techniques, the identification of interactions between nucleosome remodelers and ncRNAs has emerged as important in regulating one another and function. In several cases, these interactions have been shown to modulate the activity and targeting of nucleosome remodelers [13,14]. We discuss current literature of regulatory interactions between nucleosome remodelers and ncRNAs and provide perspective on questions that, if addressed, could clarify this interesting and important trend in chromatin biology
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