Non-coding RNA in drug resistance of hepatocellular carcinoma.

Bisha Ding,Liang Xu,Weimin Fan,Weiyang Lou

doi:10.1042/bsr20180915

Abstract

Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC. In this review, we first overviewed up-to-date findings regarding miRNA and lncRNA in drug resistance of HCC, then summarized specific mechanisms that they modulate chemoresistance of HCC, and finally discussed their potential clinical application in overcoming the obstacle of HCC chemoresistance in the future.

Highlights

Hepatocellular carcinoma (HCC) is one of the most frequently diagnosed cancers and the second leading cause of cancer-related deaths amongst males worldwide, which is largely caused by chronic hepatitis B virus (HBV) infection [1]
The majority of non-coding RNA (ncRNA) involved in drug resistance are miRNAs and long ncRNAs [9]. miRNAs are a class of non-coding single stranded RNA molecules, which are constituted by approximately 22 nucleotides
long non-coding RNA (LncRNA) are ncRNAs with a length more than 200 nucleotides, which have been shown to interplay with multiple ‘biological elements’ including DNA, RNA, and protein [15]

Summary

Introduction

Hepatocellular carcinoma (HCC) is one of the most frequently diagnosed cancers and the second leading cause of cancer-related deaths amongst males worldwide, which is largely caused by chronic hepatitis B virus (HBV) infection [1]. NcRNAs are involved in drug resistance in multiple types of cancer including HCC [8]. Recent studies have found an association between miRNAs and drug resistance in HCC [10,11,12,13,14].

Results

Conclusion