Non-classical B Cell Memory of Allergic IgE Responses.

Sean P Saunders,Erica G M Ma,Maria A Curotto De Lafaille,Carlos J Aranda

doi:10.3389/fimmu.2019.00715

Sean P Saunders, Erica G M Ma + Show 2 more

Open Access

https://doi.org/10.3389/fimmu.2019.00715

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Journal: Frontiers in Immunologie	Publication Date: Apr 26, 2019
Citations: 65	License type: CC BY 4.0

Affiliation: New York University

Abstract

The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory.

Highlights

Reviewed by: Hannah Gould, King’s College London, United Kingdom Menno C. van Zelm, Monash University, Australia
We have accumulated considerable knowledge into the mechanics of the generation of IgE immune responses from studies in mice. These studies have demonstrated that mouse IgE cells follow a unique differentiation pathway characterized by an impaired germinal center phase, the predominance of the plasma cell phenotype, and a dependence on sequential switching to generate high affinity IgE
Recent work has identified the subset of IgG1 memory cells that gives rise to high affinity IgE plasma cells

Summary

Introduction

Reviewed by: Hannah Gould, King’s College London, United Kingdom Menno C. van Zelm, Monash University, Australia. Subsets of secondary lymphoid organ memory IgG1 cells that preferentially give rise to plasma cells or germinal center cells after activation in secondary responses were identified in mice [14, 37]. A number of studies have provided strong evidence that the memory for IgE responses depends on IgG1 memory cells that class switch and differentiate to IgE plasma cells [14, 82, 84, 85].

Results

Conclusion