Abstract

Purpose: The Innovative Medicines Initiative - Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) consortium is a longitudinal cohort study to combine conventional and new disease markers and to identify different OA phenotypes. Historical data were used to train machine learning models to provide a structural and pain progression score for each individual, which was used as basis for inclusion 1. Study parameters used to assess structural progression include quantitative MRI of cartilage including thickness and semi-quantitative MRI scoring of cartilaginous and non-cartilaginous features of OA.

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