Non-Association of Toll-Like Receptor 2 rs3804099 Polymorphism with Paediatric Tuberculosis in South Africa

Inyang U Udosen

doi:10.7176/alst/74-06

Abstract

Genetic polymorphisms are important risk factors that are involved in development and severity of disease infections especially tuberculosis. In this study, a non-synonymous single nucleotide polymorphism of immune response protein gene, toll-like receptor 2 (TLR2) occurring in exon 2 (rs3804099) was carried out by genotypic analysis of cases and controls for tuberculosis. The paediatric study population consisted of 151 cases and 82 controls obtained mainly from Xhosa ethnic group.Result from this study showed that this non-synonymous single nucleotide polymorphism of TLR2 was not associated with tuberculosis (p= 0.38). Keywords : Tuberculosis, Toll-like Receptor 2, Paediatrics, Single Nucleotide Polymorphisms DOI : 10.7176/ALST/74-06 Publication date :May 31 st 2019

Highlights

Toll-like receptors are type 1 transmembrane proteins which detect microbes that have breached the physical barriers such as skin or intestinal tract mucosa and activate immune cell responses
4.0 DISCUSSION In the study of rs3804099 polymorphism of toll-like receptor 2 (TLR2), it was observed that they had no association with the tuberculosis disease in this study population and even within ethnic groups
The rs3804099 C/T polymorphism was found in 148 out of 151 cases and in 81 out of 82 controls. This polymorphism in the study population showed a genotype distribution having a predominance of heterozygotes across all groups studied

Summary

Introduction

Toll-like receptors are type 1 transmembrane proteins which detect microbes that have breached the physical barriers such as skin or intestinal tract mucosa and activate immune cell responses. They play a major role in the innate immune system. Takeda and colleagues (2003) reported that the signaling pathway of Drosophila Toll has similarity with mammalian IL-1 pathway that causes activation of NF-κB, a transcription responsible for many reactions of inflammatory and immune responses. They suggested that the toll pathway in drosophila is necessary for resistance to Gram-positive bacterial infections in addition to fungal infections. The TLR2 gene consist of two exons but all the coding sequence is in exon 2

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