Abstract

(−)-2,3:4,6-Di- O-isopropylidene-2-keto- l-gulonic acid [(−)-DIKGA] has been introduced as a chiral counter ion in non-aqueous capillary electrophoresis. High enantioresolutions ( R S ≥3) were obtained for amines, e.g., pronethalol, labetalol and bambuterol. Methanol containing NaOH and (−)-DIKGA was used as the background electrolyte. The counter ion concentration and the nature of the injection medium were found to affect the chiral separation. Covalent coating of the fused-silica capillary reduced the electro-osmotic flow resulting in improved enantioresolutions.

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